RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-495
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
RT-PCR; dual-luciferase reporter assay;
Target
NA
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
"MicroRNA-495 inhibits the high glucose-induced inflammation, differentiation and extracellular matrix accumulation of cardiac fibroblasts through downregulation of NOD1"
Year
2018
Function
"Upregulation of miR-495 ameliorates the high glucose-induced inflammatory, cell differentiation and extracellular matrix accumulation of human cardiac fibroblast by modulating both the NF-KB and TGF-beta1/smad signaling pathways through downregulation of NOD1 expression."